Name | Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) |
Synonyms | AMI1 AMI 1 AMI-1 AMI-1 - AMI-1 sodium salt Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate) 7,7'-(carbonyldiimino)bis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-2-naphthyl)carbamoylamino]naphthalene-2-sulfonate disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate disodium 4-hydroxy-7-[(5-hydroxy-7-sulfonato-naphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate |
CAS | 20324-87-2 |
EINECS | 243-735-4 |
Molecular Formula | C21H17N2NaO9S2 |
Molar Mass | 528.48 |
Appearance | Brown solid. |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Physical and Chemical Properties | Pale gray paste. Soluble in water, easily soluble in alkaline solution. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.823 ml | 9.117 ml | 18.233 ml |
5 mM | 0.365 ml | 1.823 ml | 3.647 ml |
10 mM | 0.182 ml | 0.912 ml | 1.823 ml |
5 mM | 0.036 ml | 0.182 ml | 0.365 ml |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
biological activity | AMI-1 is a potent, cell-permeable, the reversible inhibitor of protein arginine N-methyltransferase (PRMTs) has IC50 values of 8.8 μm and 3.0 μm for the effect of human PRMT1 and yeast Hmt1p, respectively. AMI-1 inhibition of PRMTs by blocking peptide-substrate binding. |
Target | IC50: 8.8 μm (PRMT1), 3.0 μm (yeast-Hmt1p) |
Cell Line: | S180 cells, U2OS cells S180 cells |
Concentration: | 0.6 mM, 1.2 mM, 2.4 mM 1.2 mM, 2.4 mM |
Incubation Time: | 48 hours, 72 hours, 96 hours 48 hours, 72 hours |
Result: | Inhibited the cell viability. Increased the percentages of cells undergoing apoptosis. Decreased tumor weight. |
Animal Model: | 6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft |
Dosage: | 0.5 mg |
Administration: | Intratumorally, daily, for 7 days |
Use | used as an intermediate for azo dyes such as direct Orange S and direct acid fast red 4BS |